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This two volume set provides a comprehensive account of the entire sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians and medical practitioners.
- Includes case studies of the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil)
- Discusses the discovery of agents for the treatment and management of bacterial infections, Parkinson's disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer
- Contains chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics
The first volume of this set thoroughly describes conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and revising the drug as necessary.
- Sales Rank: #1539269 in Books
- Published on: 2006-06-16
- Original language: English
- Number of items: 1
- Dimensions: 10.30" h x 1.14" w x 7.40" l, 2.13 pounds
- Binding: Hardcover
- 476 pages
Review
"...provides a nice survey of most of the key topics facing discovery houses today." (Doody's Health Services)
"This reasonably priced book is well-written and produced. It has a useful 32-page index, and it may be considered for acquisition by individuals and libraries." (Journal of Medicinial Chemistry, October 5, 2006)
From the Back Cover
From first principles to real-world applications — here is the first comprehensive guide to drug discovery and development
Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines—from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process.
The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and development—from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing—including drug coloring and delivery methods.
Featuring contributions from a world-class team of experts, Drug Discovery and Development:
- Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil)
- Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer
- Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics
Drug Discovery and Development is an indispensable working resource for industrialchemists, biologists, biochemists, and executives who work in the pharmaceutical industry.
About the Author
Mukund S. Chorghade, PHD, is President of Chorghade Enterprises, Inc., a firm based in Natick, Massachusetts that provides consultations to major pharmaceutical companieson collaborations with worldwide academic, government, and industrial laboratories; European technology-based companies; process reengineering; and project management of technology transfer.
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